Hidrogel Berasaskan Pektin Kulit Buah Naga (Hylocereus polyrhizus) sebagai Pembawa Ubat melalui Sistem Penghantar Oral
نویسندگان
چکیده
Kajian ini memfokuskan kepada aplikasi hidrogel berasaskan ekstrak pektin daripada kulit buah naga (Hylocereus polyrhizus) yang digunakan sebagai biobahan pembawa ubat. Sebanyak 5 sampel telah disediakan dengan peratus komposisi berbeza (0%, 0.5%, 1.0%, 1.5%, 2.0%). Keputusan menunjukkan 1.0% mengembang secara maksimum pada pH 7. Imej mikroskop elektron pengimbas (SEM) mendapati saiz keporosan meningkat penambahan pektin. Potensi agen ubat dilakukan melihat kecekapan muatan ubat, ujian perlepasan dan biodegradasi di dalam saluran pencernaan menggunakan medium simulasi perut (SGF), usus (SIF) kolon (SCF) in-vitro kehadiran enzim. Hasil ketoksikan kaedah embrio ikan kuda belang (Danio rerio) memberikan keputusan negatif terhadap diuji.
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ژورنال
عنوان ژورنال: Sains Malaysiana
سال: 2021
ISSN: ['0126-6039', '2735-0118']
DOI: https://doi.org/10.17576/jsm-2021-5011-10